Identification of the Major Antioxidative Metabolites in Biological Fluids of the Rat with Ingested (+)-Catechin and (-)-Epicatechin (original) (raw)

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Institute for Fundamental Research, Suntory Ltd. (SUNBOR)

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Institute for Bioorganic Research, Suntory Ltd. (SUNBOR)

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Institute for Bioorganic Research, Suntory Ltd. (SUNBOR)

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Institute for Fundamental Research, Suntory Ltd. (SUNBOR)

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,

Institute for Fundamental Research, Suntory Ltd. (SUNBOR)

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,

Institute for Fundamental Research, Suntory Ltd. (SUNBOR)

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Institute for Fundamental Research, Suntory Ltd. (SUNBOR)

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Institute for Fundamental Research, Suntory Ltd. (SUNBOR)

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Received:

02 November 1998

Published:

01 January 1999

Accepted:

05 February 1999

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Masami HARADA, Yukiko KAN, Hideo NAOKI, Yuko FUKUI, Norihiko KAGEYAMA, Masaaki NAKAI, Wataru MIKI, Yoshinobu KISO, Identification of the Major Antioxidative Metabolites in Biological Fluids of the Rat with Ingested (+)-Catechin and (-)-Epicatechin, Bioscience, Biotechnology, and Biochemistry, Volume 63, Issue 6, 1 January 1999, Pages 973–977, https://doi.org/10.1271/bbb.63.973
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Abstract

(+)-Catechin and (-)-epicatechin are known to be biologically effective antioxidants present in the human diet, particularly in wine and tea. We studied the metabolism of these compounds to elucidate the truly active structures in biological fluids by their oral administration to rats. Without any treatment with β-glucuronidase and sulfatase, a pair of metabolites were detected at much higher concentrations in the plasma, bile, and urine than the originally ingested compounds. Each major metabolite found in the plasma at the highest concentration was excreted in both the bile and urine, and was purified from urine. Their chemical structures were established to be (+)-catechin 5-_O_-β-glucuronide and (-)-epicatechin 5-_O_-β-glucuronide by MS and NMR analyses. These glucuronide conjugates exhibited high antioxidative activities as superoxide anion radical scavengers like their parent compounds. It is concluded that (+)-catechin 5-_O_-β-glucuronide and (-)-epicatechin 5-_O_-β-glucuronide are the biologically active in vivo structures of the ingested polyphenolic antioxidants.

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© 1999 by Japan Society for Bioscience, Biotechnology, and Agrochemistry

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