Genetic Regulation of Cortical and Trabecular Bone Strength and Microstructure in Inbred Strains of Mice (original) (raw)
Journal Article
,
Biomechanics and Biomaterials Research Center, Indiana University, Indianapolis, Indiana, U.S.A.
Search for other works by this author on:
,
Biomechanics and Biomaterials Research Center, Indiana University, Indianapolis, Indiana, U.S.A.
Search for other works by this author on:
,
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, U.S.A.
Search for other works by this author on:
,
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, U.S.A.
Search for other works by this author on:
,
Loma Linda University and Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California, U.S.A.
Search for other works by this author on:
,
Maine Center for Osteoporosis Research and Education, Bangor, Maine, U.S.A.
Search for other works by this author on:
,
Connective Tissue Research Group, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Search for other works by this author on:
,
The Jackson Laboratory, Bar Harbor, Maine, U.S.A.
Search for other works by this author on:
The Jackson Laboratory, Bar Harbor, Maine, U.S.A.
Search for other works by this author on:
Revision received:
08 December 1999
Accepted:
12 January 2000
Published:
02 December 2009
Cite
Charles H. Turner, Yeou‐Fang Hsieh, Ralph Müller, Mary L. Bouxsein, David J. Baylink, Clifford J. Rosen, Marc D. Grynpas, Leah Rae Donahue, Wesley G. Beamer, Genetic Regulation of Cortical and Trabecular Bone Strength and Microstructure in Inbred Strains of Mice, Journal of Bone and Mineral Research, Volume 15, Issue 6, 1 June 2000, Pages 1126–1131, https://doi.org/10.1359/jbmr.2000.15.6.1126
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
The inbred strains of mice C57BL/6J (B6) and C3H/HeJ (C3H) have very different femoral peak bone densities and may serve as models for studying the genetic regulation of bone mass. Our objective was to further define the bone biomechanics and microstructure of these two inbred strains. Microarchitecture of the proximal femur, femoral midshaft, and lumbar vertebrae were evaluated in three dimensions using microcomputed tomography (μCT) with an isotropic voxel size of 17 μm. Mineralization of the distal femur was determined using quantitative back‐scatter electron (BSE) imaging. μCT images suggested that C3H mice had thicker femoral and vertebral cortices compared with B6. The C3H bone tissue also was more highly mineralized. However, C3H mice had few trabeculae in the vertebral bodies, femoral neck, and greater trochanter. The trabecular number (Tb.N) in the C3H vertebral bodies was about half of that in B6 vertebrae (2.8−1 ± 0.1 mm−1 vs. 5.1−1 ± 0.2 mm−1; p < 0.0001). The thick, more highly mineralized femoral cortex of C3H mice resulted in greater bending strength of the femoral diaphysis (62.1 ± 1.2N vs. 27.4 ± 0.5N, p < 0.0001). In contrast, strengths of the lumbar vertebra were not significantly different between inbred strains (p = 0.5), presumably because the thicker cortices were combined with inferior trabecular structure in the vertebrae of C3H mice. These results indicate that C3H mice benefit from alleles that enhance femoral strength but paradoxically are deficient in trabecular bone structure in the lumbar vertebrae.
Copyright © 2000 ASBMR
You do not currently have access to this article.
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Genetic Regulation of Cortical and Trabecular Bone Strength and Microstructure in Inbred Strains of Mice - 24 Hours access
EUR €46.00
GBP £40.00
USD $49.00
Rental
This article is also available for rental through DeepDyve.
Citations
Views
Altmetric
Metrics
Total Views 77
60 Pageviews
17 PDF Downloads
Since 2/1/2024
| Month: | Total Views: |
|---|---|
| February 2024 | 16 |
| March 2024 | 21 |
| April 2024 | 18 |
| May 2024 | 8 |
| June 2024 | 8 |
| August 2024 | 3 |
| September 2024 | 1 |
| October 2024 | 2 |
Citations
161 Web of Science
×
Email alerts
Email alerts
Citing articles via
More from Oxford Academic