Treatment of Terminal Peritoneal Carcinomatosis by a Transducible p53-Activating Peptide (original) (raw)
Figure 6
Tumor-Reconstituted Cells from Treated Mice Remain Sensitive to RI-TATp53C′ Peptide-Induced G1 Arrest or Apoptosis in Culture
(A) TA3/St cells were recovered from an A/J mouse treated with RI-TATp53C′ peptide and grown in DMEM/10% FBS. Recovered cells were treated with increasing concentrations of RI-TATp53C′ peptide and then analyzed for DNA content by flow cytometry 24 h later.
(B) Namalwa cells were recovered from a SCID mouse treated with RI-TATp53C′ peptide and grown in RPMI plus 10% FBS. Recovered cells were treated with increasing concentrations of RI-TATp53C′ peptide. After 2 d, the number of viable cells was assessed by Trypan blue exclusion and normalized to the number of viable untreated cells. Mean and standard deviation of multiple experiments are depicted.