α-Actinin-4-Mediated FSGS: An Inherited Kidney Disease Caused by an Aggregated and Rapidly Degraded Cytoskeletal Protein (original) (raw)
Figure 6
Biochemical Characteristics of Mutant Mice
(A) Average BUN and creatinine levels in _Actn4_K228E/– (n = 12), Actn4+/+ (n = 8), and _Actn4_K228E/K228E (n = 12) mice at the time of sacrifice. Differences were not statistically significant. Error bars show standard deviation.
(B) Summary of proteinuria in wild-type, Actn4+/–, _Actn4_K228E/–, _Actn4_–/–, and _Actn4_K228E/K228E mice, measured by albumin dipstick. Distribution of measurements are illustrated graphically for each genotype.