Components of Coated Vesicles and Nuclear Pore Complexes Share a Common Molecular Architecture (original) (raw)
Figure 5
Proposed Model for the Evolution of Coated Vesicles and Nuclear Pore Complexes
Early eukaryotes (left) acquired a membrane-curving protein module (purple) that allowed them to mold their plasma membrane into internal compartments and structures. Modern eukaryotes have diversified this membrane-curving module into many specialized functions (right), such as endocytosis (orange), ER and Golgi transport (green and brown), and NPC formation (blue). This module (pink) has been retained in both NPCs (right bottom) and coated vesicles (left bottom), as it is needed to stabilize curved membranes in both cases.