Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages (original) (raw)
Figure 5
Critical Role for STAT-1 in Limiting MNV-1 Growth In Vitro
(A) MNV-1.CW1 has no defect in viral growth in vitro. Growth curves (MOI of 0.05) were performed two or three times with MNV-1.CW1 (P3) on indicated cells to calculate standard deviations.
(B) MNV-1 growth in MΦ is controlled by STAT-1 and Type I IFNs. BMMΦ of the indicated genotype were infected with MNV-1.CW1 (P3) at the indicated MOI. The experiment was performed twice to calculate standard deviations. The _p_-values for PKR versus wt infection at MOI 0.05 and 2.0, 0.8867 and 0.1616, respectively, are not significant. Statistical analysis was performed using the paired _t_-test (GraphPad Prism, version 3.03).