Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance (original) (raw)
Figure 1
Survival and Mutation of E. coli Mutants In Vivo after Starting Antibiotic Therapy
Survival and mutation of Δ_lacZ_ and lexA(S119A) mutants of E. coli ATCC 25922 in thighs of neutropenic mice at 24-h intervals after starting therapy with (A) ciprofoxacin or (B) rifampicin. Open circles and triangles correspond to the total cfu/thigh of the Δ_lacZ_ and lexA(S119A) strains, respectively. Solid circles and triangles represent the number of drug-resistant Δ_lacZ_ and lexA(S119A) cfu/thigh, respectively.