Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells (original) (raw)
Figure 8
Domain Structure of Loqs and Its_Homo sapiens_ and Xenopus Homologs
The dsRNA-binding motif (dsRBD) is indicated as a black box. These proteins contain three putative dsRBDs. Loqs shares ∼34% amino acid identity with TRBP and PACT and ∼31% identity with Xlrbpa (Xenopus laevis RNA-binding protein A). Sequence comparison between Loqs and its human and Xenopus homologs also showed a higher degree of amino acid conservation in dsRBDs including C-terminal non-canonical dsRBDs. The_Xenopus_ homolog, Xlrbpa, of TRBP/PACT has been found to associate with ribosomes in the cytoplasm [77], as is the case for many RNAi factors including miRNAs [47,78−82].