Precise Temporal Modulation in the Response of the SOS DNA Repair Network in Individual Bacteria (original) (raw)
Figure 4
Dependence of Response Parameters on UV Dose
(A) Percentage of cells exhibiting at least zero, one, two, or three peaks at different damage levels. (B) Dependence of the mean peak time <_Ti_>, normalized by T = (1/TD + 1/τ)–1 (τ = 68 min), on UV dose. (C) Dependence of the mean normalized peak height <PA_i_>/PA0 on UV dose. Wild type (full symbols), ΔumuDC (empty symbols). Same color and symbol convention as in (B): <PA1>/PA0 (red circles), <PA2>/PA0 (blue triangles), and <PA3>/PA0 (green diamonds). In wild-type cells, the amplitude of peaks saturates at approximately 20 PA0 for UV doses greater than 20 J/m2. ΔumuDC cells do not show this saturation and reach much higher PA levels. Parameters in (A), (B), and (C) are from measurements performed with the recA promoter.