A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain (original) (raw)
Figure 2
Molecule B Closely Resembles the Structure of the Inactive Src Kinases
(A) The kinase domain of Abl (molecule B) is shown as a cartoon with the bisubstrate analog inhibitor depicted as a stick model.
(B) Structure of the ATP–peptide conjugate at the active site.
(C) Comparison between molecule B (left) and the structure of a Src-family kinase (right).
(D) Backbone torsion angles of Asp 381 of the DFG motif.
(E) The backbone of Asp 381 can start to move from DFG-In to the DFG-Out conformations by three paths in torsion angle space [32].
(F) Illustration of rotations about φ(Asp 381) and ψ(Asp 381) in the Src-like inactive versus the active structures of Abl.