AgDscam, a Hypervariable Immunoglobulin Domain-Containing Receptor of the Anopheles gambiae Innate Immune System (original) (raw)
Figure 3
AgDscam Is Implicated in Anti- Plasmodium Defense
RNAi-mediated depletion of AgDscam from adult female mosquitoes resulted in increased permissiveness to P. berghei infection, as indicated by a 59%–99% increase in oocysts numbers in four independent assays.
The figure presents the frequency distributions of oocysts pooled from four independent assays where MI indicates mean intensity of infection (oocysts number) plus/minus standard error, and n indicates the total number of mosquitoes in each experiment. Infection levels in _AgDscam_-silenced mosquitoes were comparable to the positive control _Tep1 dsRNA_-treated mosquitoes [44].