Peptides Encoded by Short ORFs Control Development and Define a New Eukaryotic Gene Family (original) (raw)
Figure 5
The tal Transcript in Drosophila and Other Species
(A) LP10384 cDNA sequence with conceptual ORF translation; putative peptide identity is indicated on the right. Kozak consensi surrounding the start codons are underlined. Conserved domains in the type-A peptides are in bold type.
(B) Graphic representation of tal and its homologs in other species, represented either by cDNAs (arrow ends) or genomic sequences (blunt ends). Type-A ORFs are represented by red boxes, and ORF-B by blue boxes. The tal gene family is at least 440 million years old and includes divergent orthologs and paralogs with different numbers of type-A ORFs. Note also that the gene duplication events in Bombyx and Lutzomia are independent. The ancestral gene had only two type-A ORFs, as shown by crustaceans and primitive insects.