Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (original) (raw)
Figure 1
Spatial Learning in a Water Maze Increases Cell Death and Decreases Cell Genesis in the Dentate Gyrus
(A) Latency to find the escape platform. The syringes represent BrdU injections.
(B–D) Apoptotic cell death measured by the number of fractin-IR cells (B), active-caspase-3-IR cells (C), and both pyknotic and karyorrhexic dying cells (Apoptotic cells) (D).
(E) Cell genesis measured by the number of BrdU-IR cells.
C, Control group; D, day; L, Learning group; Y, Yoked group.
A single asterisk (*) indicates p ≤ 0.05, double asterisks (**) indicate p ≤ 0.01, and triple asterisks (***) indicate p ≤ 0.001 compared to Control. A single circle (°) indicates p ≤ 0.05, double circles (°°) indicate p ≤ 0.01 compared to Yoked. Error bars represent the standard error of the mean (s.e.m.).