Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (original) (raw)
Figure 7
Learning Increases the Number of New Neurons, and This Effect Is Blocked by zVAD Infusion
(A) Latency to reach the hidden platform in animals infused with zVAD (•) or vehicle (○). The dashed line represents the mean escape latency across the first four training days. The syringes represent IdU and CldU injections. D, day.
(B) Effects of zVAD (filled bars) and vehicle (open bars) treatments on the survival of IdU-IR cells generated 7 d before exposure to the task.
(C) Effects of zVAD (filled bars) and vehicle (open bars) treatments on the number of IdU-IR cells exhibiting characteristics of pyknotic cells.
(D) Effects of zVAD (filled bars) and vehicle (open bars) treatments on the survival of CldU-IR cells generated 3 d before exposure to the task.
(E) Effects of zVAD (filled bars) and vehicle (open bars) treatments on the number of CldU-IR cells exhibiting characteristics of pyknotic cells.
A single asterisk (*) indicates p ≤ 0.05, double asterisks (**) indicate p ≤ 0.01, and triple asterisks (***) indicate p ≤ 0.001, zVAD group compared to Veh group; a single circle (°) indicates p ≤ 0.05, double circles (°°) indicate p ≤ 0.01, and triple circles (°°°) indicate p ≤ 0.001, Learning group (L) compared to Control group (C) .