Quantitative Characteristics of Gene Regulation by Small RNA (original) (raw)
Figure 5
Comparison between sRNA- and Protein-Mediated Repression
(A) Steady-state solution of model (1), with the estimated parameters of Table 1. The strength of sRNA repression decreases as the target transcription increases. (B) Steady-state solution of a model for protein regulators (Supporting Text S1), where the strength of repression is independent of target transcription rate. (C) Temporal behavior in a single stochastic simulation [94] of the expression of two model genes, geneA (blue line) and geneP (red), regulated by sRNA and protein regulators respectively. For geneA we set α_A_ = 1/min and kA = 0.02/min, while for geneP we have αP = 0.0043/min and kP = 0. All other parameters are taken from Table 1 and are identical for both genes. This choice of parameters makes the mean mRNA levels of the two genes equal. The bursty nature of the noise for geneP is compared with the smooth fluctuations exhibited by geneA.