Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae (original) (raw)
Figure 1
Genome-Wide Screen for Phenotypic Capacitors in S. cerevisiae
(A) Schematic of some quantitative phenotypes in a budded cell: (a) long axis length of the mother nucleus, (b) long axis length in the mother cell, (c) maximal distance between actin patches, (d) bud angle. A full list of phenotypes and their descriptions is reported in Ohya et al. [17].
(B) Scatter plots of means and standard deviations for 4,718 YKO strains for two phenotypes clearly indicate that variance depends on mean in a nontrivial, phenotype-specific manner. Black circles represent individual YKOs and red circles represent the lowess curve fit.
(C) Histograms of actual (red) and 100 randomized (grey) phenotypic potential scores. Shown are the ranges of the three phenotypic capacitor classes (C1, C2, C3).