Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae (original) (raw)
Figure 4
Characteristics of Capacitor Duplicates
(A) The average number of affinity-capture mass spectrometry interactions of all nonessential genes (grey), all nonessential singletons (light green), capacitor singletons (light blue), all nonessential duplicates (dark green), and capacitor duplicates (dark blue).
(B) Ks (left) and the expression similarity (right) between duplicate pairs that contain at least one essential gene (dark grey), at least one capacitor (solid dark blue), only nonessential noncapacitor genes (solid light grey), at least one gene product with over 19 PPIs annotated in the literature-curated BioGRID network and at least one capacitor (dark blue stripes), and at least one gene product with over 19 PPIs and no capacitors or essential genes (light grey stripes).
(C) The mRNA abundance (left), protein abundance (middle), and SLI degree (right) of capacitors with only one paralog in the genome (blue) and their paralogs (green).
(D) The phenotypic potential of capacitors with only one paralog in the genome (blue), their paralogs (green), and all nonessential genes (grey). Error bars represent the standard error of the mean. Unless otherwise marked, _p_-values are a comparison to duplicate capacitors, Wilcoxon-Mann-Whitney test: *, p < 0.05; **, p < 0.001; ***, p < 1 × 10−5; ****, p < 1 × 10−10.