Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse (original) (raw)
Figure 4
The distribution of segmental duplication in MGSCv3 (top) and Build 36 (bottom).
Interchromosomal (red) and intrachromosomal (blue) duplications (>95% identity and >10 kbp) in length are shown for both genome assemblies with the requirement that pairwise alignments are shown for only those regions (Build 36) that are also confirmed by the WGS depth of coverage analysis (black vertical bars/ticks). Positions of the centromeres (acrocentric) are shown (purple) for the MGSCv3 build. Initial estimates predicted the amount of segmental duplication to be approximately 1.5–2% of the genome. Calculations performed using Build 36 suggested the amount is much higher, approximately 4.5–5%. In addition, >60% of duplicated sequences were unplaced in the MGSCv3. In Build 36, almost all are assigned to a chromosome