A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers (original) (raw)
Figure 1
Sites of regulated extragenic transcription upstream of LPS-inducible genes.
(A) Pol_II ChIP-Seq data from unstimulated and LPS+γIFN-stimulated macrophages at the Ccl5 gene and surrounding genomic regions. The extragenic Pol_II peaks (indicated as −1, −2, and −3) and the genomic annotations (mm9) are shown. The _y_-axis indicates the number of ChIP-Seq tags. (B) Phosphorylated Ser5 Pol_II ChIP-Seq data at the same genomic region. UT, untreated macrophages.