Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results (original) (raw)
Figure 2
Frequency distributions of a) the risk allele frequency of the most associated SNPs listed in the GWAS Catalog [1] for the diseases in Table 3.
b) MAF of all SNPs simulated under the coalescence model, c) MAF of SNPs used in analyses to be representative of SNPs included in GWAS. d–f) Coupled allele of most associated SNP from simulations of 1, 9, or 36 causal variants in a 100 kb region.