A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis (original) (raw)
Figure 8
A simplified canonical model of mammalian CME.
A simplified schematic illustrating the relative timing of recruitment of the seven different endocytic protein modules to sites of scission, highlighting some unexpected findings for future investigation. The patterns of recruitment are the same for terminal events (Ai) and non-terminal events (Aii). The heterogeneous size of endocytically productive CCSs is most easily explained if clathrin-coated buds formed at the edges of clathrin patches of variable size, thus accounting for the variability in fluorescence of endocytically active CCSs (Aii). Repeat scission events most likely occurred by re-growth of clathrin-coated invaginations at the edge of “host” patches of clathrin (lower curved arrow, [Aii]).