Metabolic Erosion Primarily Through Mutation Accumulation, and Not Tradeoffs, Drives Limited Evolution of Substrate Specificity in Escherichia coli (original) (raw)
Figure 2
Relative growth rates across a variety of growth substrates for evolved strains from 20k (A) or 50k generations (B).
Heatmaps indicate the log ratio of growth rates relative to the average of the two ancestors on that carbon source. White indicates a growth rate equal to that of the ancestor average, red faster, and blue slower. The growth rates are plotted on a log scale with the limits of the color range set for twice as fast and half as fast as the ancestor average. An “x” in a box indicates that no growth was observed for that combination of strain and substrate over 48 h. Strains that were mutators by that time point are indicated.