Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection (original) (raw)
Fig 1
Schematic illustration of the evolvability of antibiotic resistance under three scenarios.
A strain’s evolvability is defined operationally as the maximum increase in resistance from an initially susceptible genotype during one round of drug selection. (A) Null model, with no effect of genetic background on evolvability. (B) Diminishing-returns model, such that backgrounds with low initial resistance are more evolvable than backgrounds that are initially more resistant. (C) Idiosyncratic-effects model, in which evolvability varies among genetic backgrounds but is uncorrelated with their initial level of resistance. MIC, minimum inhibitory concentration.