A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes (original) (raw)
Figure 1
Distribution of the Different CRISPR/Cas Subtypes across Some of the Prokaryotic Species for Which a Whole-Genome Sequence Is Available
The taxonomy of each species/strain is indicated on the left side of the figure. The CRISPR/cas loci of a number of illustrative examples for the different CRISPR subtypes are displayed on the right side of the figure.
a_E. coli_ K12-MG1655, O157:H7 EDL933, and O157:H7 VT2-Sakai.
b_Salmonella enterica_ Paratyphi ATCC9150, serovar Typhi CT18, and Ty2; Salmonella typhimurium LT2 SGSC1412.
c_Y. pestis_ CO92, KIM, and biovar Mediaevalis 91001; Yersinia pseudotuberculosis IP32593.
d“_p_” indicates a partial cluster lacking some of the genes usually associated with this subtype, the repeats, or both. Such clusters may represent autonomous functional units, degradation from the common subtype, or cases in which the missing components are supplied by distantly located CRISPR clusters within the same genome.