Simulating Properties of In Vitro Epithelial Cell Morphogenesis (original) (raw)
Figure 9
An Appropriate Response by Analogue 2
An appropriate response is demonstrated by Analogue 2 in the previously invalidating experiment described in Figure 6. This experiment determined that inclusion of pcells in Analogue 2 provides some resistance to the unacceptable, dramatic behavior of Analogue 1. Sketched are screen shots taken during a typical simulation. Pcells are shaded darker than cells. Spaces are shaded as defined in Figure 8. First, a stable monolayer of pcells was formed. The simulation was stopped. A layer of cells was placed on top of the pcell monolayer (top: cycle 0). The simulation was restarted. End of cycle 1: many of the added cells have “died,” and a few of the original pcells have transitioned to cell status. Cycle 5: some minor remodeling of the original layer of matrix has occurred; compare with cycle 2 in Figure 6. Cycle 15: a stable structure has formed dominated by pcells; some inverted cysts remain above the pcell monolayer.