Large-Scale Turnover of Functional Transcription Factor Binding Sites in Drosophila (original) (raw)
Figure 5
Functional Nonconserved Binding Sites Are Enriched in Bound Regions
The average number of nonconserved Zeste binding sites per kb within 300 bp of peaks in the bound regions (unfilled bars) and the flanking noncoding regions (grey bars). The threshold p = 0.01 was used for the T statistic with the HB model as the null distribution to identify nonconserved binding sites. As a control for base composition, rate of evolution, or other local sequence effects, the numbers of nonconserved matches to a scrambled version of the Zeste specificity matrix in the same regions are also shown. Error bars represent the standard error of the proportion.