Posttranscriptional Expression Regulation: What Determines Translation Rates? (original) (raw)
Figure 2
Saturation of the Transactional Activity
Shows Spearman rank correlation (rs) of different models for TA prediction as a function of the Michaelis constant, Km. All four factors (F) contributing to TA (mRNA, ribocc, ribden, CAI) were tested for saturation individually and in combination. The different colors indicate the models for TA prediction:
The product of mRNA × ribocc × ribden in the saturation term (i.e., TA3) yielded the best correlation with reference protein concentrations. The value without any saturation (rs = 0.68) is approached for Km → ∞.