Efficiency, Selectivity, and Robustness of Nucleocytoplasmic Transport (original) (raw)
Figure 4
Karyopherins Efficiently Exclude Nonspecifically Binding Macromolecules from the NPC
Shown is the transport efficiency of particles across the NPC as a function of interaction strength with the FG-repeat regions, either in the presence or absence of competing particles. Gray line: transport efficiency of particles as a function of interaction strength in the absence of competition. Red line: transport efficiency of a weakly binding species in an equal mixture of weakly and strongly binding species, as a function of the interaction strength of the weakly binding species; the interaction strength for the strongly binding species is 12kBT. Translocation of the weakly binding species is sharply reduced in the presence of the strongly binding species, until its binding strength approaches that of the strongly binding species. No RanGTP activity was included in these simulations, hence lowering the transport efficiency compared with Figure 3.