Efficiency, Selectivity, and Robustness of Nucleocytoplasmic Transport (original) (raw)
Figure 5
Discrete Overlapping FG-Repeat Regions Can Be Approximated by a Smooth Effective Potential
Transport through the NPC can be represented as diffusion in an array of potential wells (solid black lines) that represent flexible FG-repeat regions whose fluctuation regions overlap. The red dotted arrows correspond to the complexes unbinding from and rebinding to the FG-repeat regions. The solid blue line represents the unbound state. The solid red line shows the equivalent potential in the case when the unbinding of the complexes from the FG-repeat regions is much faster than the lateral diffusion across an individual well.