Global and Local Architecture of the Mammalian microRNA–Transcription Factor Regulatory Network (original) (raw)
Figure 1
miRs and Target Genes in the TargetScan Dataset
(A) Distribution of the number of different miRs regulating each target gene in the TargetScan dataset. The thick red line represents the distribution in the original datasets, while each of the thin blue lines represents the distribution in one of the column-randomized matrices. The matrix contains only genes with at least one predicted site in their 3′ UTR. In each randomization, we shuffled the assignment of miRs to their targets, keeping constant the number of targets per miR.
(B) Distribution of number of targets per miR in the TargetScan dataset. In the thick red line we depicted the original distribution, while each blue thin line represents the distribution in one of the 100 row-randomized matrices, which preserve the distribution of number of miRs targeting each gene.