Phenotypic Mutation Rates and the Abundance of Abnormal Proteins in Yeast (original) (raw)
Figure 5
Selection for Translational Robustness as a Function of Amino Acid Substitution Rate
The top panel shows the average amount of abnormal proteins,x̄, after 500,000 cycles of mutation and selection (see text for more detail). The mid-panel shows the average log-likelihood (LL) of the m-neutralities after selection. For u ≥ 1.92 × 10−5, the average LLs are significantly lower than expected by chance. The 5 (0.1) quantile is given by −25.024 (−25.040). The total LL decreases noticeably for _u_aa > 5 × 10−4. The lower panel shows the average LL of three groups of 100 proteins. We consider the 100 largest proteins, the 100 most highly expressed proteins, and the 100 proteins with the largest . For 100 proteins, the 5% (0.1%) quantile for the average LL is −25.117 (−25.215). The lower panel shows that the extent of selection for translational robustness increases nonlinearly for large proteins whereas it increases approximately linearly in the other two groups of proteins.