Determination of the Processes Driving the Acquisition of Immunity to Malaria Using a Mathematical Transmission Model (original) (raw)
Figure 6
Schematic Illustration of the Full Transmission Model for Humans and Mosquitoes (without Explicit Ageing in Humans)
States are shown in circles, and subscripts denote the population (H = humans, M = mosquitoes): susceptible SH/SM, latent infection EH/EM, infected with symptomatic disease (severe and clinical cases) DH, asymptomatic patent infection AH, infected with undetectable (subpatent) parasite density UH, infectious mosquitoes IM. ΛH /ΛM is the force of infection on the human and mosquito populations, respectively, 1/h is the mean latent period in humans, 1/g the mean latent period in mosquitoes, φ is the proportion of human infections that develop disease, f the proportion of symptomatic cases that receive effective drug treatment, rT the rate of recovery on treatment, rD the rate of recovery without treatment, rA the rate at which asymptomatic infections become subpatent, and rU the rate at which subpatent infections are cleared. The coloured circles denote the stages at which acquired immunity can have an effect (modifying φ, rA, and rU). The parameters and their values are described in Table 1.