Entropy Measures Quantify Global Splicing Disorders in Cancer (original) (raw)
Figure 3
Meta-analysis method to obtain proliferative indices of cancer samples in microarray experiments.
The 188 genes of the “cell cycle” cluster in the conserved coexpression network identified by Stuart et al. [26] were extracted. Each of the 3787 cancer-related samples was classified in one of 5 separate bins of same size in function of the average expression level of these 188 genes. The high proliferation signature bin (High PS) corresponds to the 20% of samples that have the highest mean expression level of the 188 genes; the lowest proliferation signature bin (Low PS) corresponds to the 20% of samples that have the lowest mean expression level of the 188 genes.