Allosteric Transitions of Supramolecular Systems Explored by Network Models: Application to Chaperonin GroEL (original) (raw)

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Figure 2

Schematic description of _a_ANM method.

Two sets of intermediate conformations are generated, and (1≤k_≤_ktot), starting from the known substates and , illustrated here for k = 1 and 2. The distance vector between the instantaneous endpoints at the kth step is denoted as , and the deformation at each step is or . Dashed ellipses indicate isoenergetic contours.

doi: https://doi.org/10.1371/journal.pcbi.1000360.g002