Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis (original) (raw)

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Figure 1

Ligand binding site similarity between COMT and InhA.

COMT is show in green, its SAM co-factor is shown in purple, and its ligand is shown in red. InhA is shown in blue, its NAD co-factor is shown in orange, and its ligand is shown in yellow. Protein structures were aligned using the SOIPPA algorithm.

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1000423.g001