A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network (original) (raw)
Figure 9
Effect of _D_O2.−i or etSOD on the propagation rate of ΔΨm depolarization wave.
A and B) Increasing _D_O2.−i by two orders of magnitude (from 4×10−11 to 4×10−9 cm2 s−1) accelerated wave propagation from 155 to 486 µm s−1. C and D) decreasing etSOD from 1.43 to 1.33 mM decreased the propagation time from 126 to 110 ms. shunt = 0.14, etSOD = 1.43 µM and _D_O2.−i = 4×10−9 cm2 s−1 except where specifically indicated. Other parameters and initial conditions were the same for all mitochondria (Supplemental Materials, Tables S2 and S3).