A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network (original) (raw)
Figure 10
Depolarization of even a single mitochondrion can evoke ΔΨm collapse of almost the entire network when a cell is at the edge of criticality.
Mitochondrial depolarization was triggered with a laser flash (1×1 pixel) in cardiomyocytes labeled with 100 nM TMRE. Frame acquisition was every 500 msec. Other imaging conditions were as described in Materials and Methods.