Drug-Induced Regulation of Target Expression (original) (raw)
Figure 2
Analysis of systematic biases and benchmarking with independent features of chemicals.
(A) Distributions of the DIPS scores for the pair-wise comparisons of gene expression profiles constructed using biological controls and mean centering as background across four drug/batch categories: i) both profiles are from the same drug and the same batch (Blue), ii) the same drug from different batches (Red), iii) different drugs from the same batch (Yellow) and iv) different drugs from different batches (Grey) (B) ROC curves are used to assess the performance of the DIPS score (blue line) and provide a comparison with the method described in Iorio et al. (red line) [9]. Area under the curve values for each ROC curve: Chemical structural similarity: AUC (DIPS = 0.028 for FPR<0.1) and (AUC Iorio et al. = 0.016 for FPR<0.1). For 4th level ATC sharing, the AUC (DIPS = 0.016 for FPR<0.1) and (AUC Iorio et al. = 0.009 for FPR<0.1)(Refer to Figure S2 for the complete ROC plots.).