Standing Genetic Variation and the Evolution of Drug Resistance in HIV (original) (raw)
Figure 4
Probability of the establishment of DRMs as a function of effective population size and the fitness of the resistant mutant during treatment.
The predicted probability of the establishment of drug resistance mutations from standing genetic variation depending on the effective population size and the fitness of the resistant mutant during therapy. Grey scales indicate the probability of the evolution of drug resistance due to standing genetic variation. Dots indicate estimated parameter combinations for treatment with just sdNVP, with ZDV monotherapy followed by sdNVP (ZDV/sdNVP), with sdNVP followed by two additional drugs postpartum (sdNVP/PP) and with ZDV monotherapy followed by sdNVP and two additional drugs postpartum ZDV/sdNVP/PP.