Improving Pharmacokinetic-Pharmacodynamic Modeling to Investigate Anti-Infective Chemotherapy with Application to the Current Generation of Antimalarial Drugs (original) (raw)
Figure 3
Panels A–F, changes in parasite clearance times associated with increasing drug resistance.
Changes in parasite clearance times (PCT) associated with either increasing AS/AR IC50 (panels A–B), increasing DHA IC50 (panels C–D) or simultaneously increasing both AS/AR and DHA IC50 (panels E–F). Left-hand column includes AS-MQ treatment and the right-hand column AR-LF treatment. Note that PCTs for monotherapies are shown as columns to the immediate right of the x-axis.