Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics (original) (raw)
Figure 1
Three steps terminology construction, from PheWAS codes based on ICD-9-CM to PheWAS codes based on ICD-10 using ICD-9-CM-A to ICD-10-AM mapping file and manual mapping.
PheWAS: Phenome-wide association study; ICD: International classification of diseases; ICD-9-CM: International classification of diseases clinically modified; ICD-9-CM-A: Australian version of the ICD-9-CM, with custom codes added. ICD-10-AM: Australian version of the ICD-10, with custom codes added. 1: Mapping file from the New-Zealand Ministry of Health was used to project ICD-10 codes on ICD-9-CM. 2: Mapping of the previous projection with existing ICD-9-CM PheWAS codes. 3: File with correspondence between ICD-10 codes and ICD-9-CM PheWAS codes.