Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics (original) (raw)
Figure 5
Manhattan plot of −log10 (P-values) for the 256 ICD-10 based aggregated codes between very high TPMT activity patients and other TPMT activity patients.
ICD-10: International classification of diseases 10; TPMT: thiopurine _S_-methyltransferase. The dotted line represents a P-value of 0.05 and the dashed line represents the FDR corrected level of significance for q = 0.2.