Assembly of Nsp1 Nucleoporins Provides Insight into Nuclear Pore Complex Gating (original) (raw)
Figure 2
Bundle thickness distribution.
Bundle thickness is determined by the number of Nsp1-FG chains involved in a bundle. Shown is here the distribution of these numbers for the simulations carried out. The frequencies with which chain numbers arise were averaged for the last 30 ns of the four simulations wild-type_ring, mutant_ring, random_array, and random_bath. Bundles with fewer than ten Nsp1-FG chains favor a mesh-like structure, namely bundles with frequent cross-links, whereas bundles with more than ten Nsp1-FG chains exhibit brush-like structures with relatively few cross-links. Green represents the frequency distribution of Nsp1-FGs for simulation wild-type_ring, red for mutant_ring, cyan for random_array, and purple for random_bath.