Assembly of Nsp1 Nucleoporins Provides Insight into Nuclear Pore Complex Gating (original) (raw)
Figure 8
Schematic model for the structural assembly of nups in the NPC channel.
The strands in black represent bundles of two or more Nsp1-FG chains. The frequency of cross-linking is higher in the central region, a feature that can be identified with the assembly of nups formed in simulation random_bath (inset in purple) characterized as a sieve-like mesh; in the periphery, brush-like bundles with less cross-linking arise and the respective structure can be identified with the ones developed in simulations random_array (inset in blue) and wild-type_ring (inset in green).