A New Model for Pore Formation by Cholesterol-Dependent Cytolysins (original) (raw)
Figure 7
Prepore conformation of the CDC molecule.
A. View of the CDC monomer in the prepore conformation within the cryo-EM map (transparent surface). B. Overall oligomeric arrangement within the cryo-EM map. Only the tetramer used in the modeling is shown (see Methods). C. Structural alignment of the ILY IB conformation (pale green) to the prepore conformation (pale orange) (4.4 Å; 448 positions). D. Prepore conformation in the context of representative CDC crystallographic structures.