A New Model for Pore Formation by Cholesterol-Dependent Cytolysins (original) (raw)
Figure 8
Pore conformation of the CDC molecule.
A. Cut view of the CDC monomer in the pore conformation within the cryo-EM map (transparent surface). B. Subunits arrangement in the pore (cut view). The tetramer shown is the symmetrically modeled tetramer (see Methods). Subunits have alternate colouring with Domain 2 coloured green. C. Domains 2 arrangement in the pore viewed from outside of the ring. A Domain 2 is highlighted in green sandwiched by two adjacent monomers. D. Prepore and pore conformations aligned on Domain 4. Prepore Domain 2 is in orange; pore Domain 2 is in green.