Integrated Modeling of Gene Regulatory and Metabolic Networks in Mycobacterium tuberculosis (original) (raw)
Fig 4
Representative time-course growth and metabolic activity of wild-type and _whiB4_-overexpression strains of MTB after treatment with drugs ethionamide (ETH) and isoniazid (INH).
(A, C) The growth time-courses measured by OD600 of wild-type (blue) and _whiB4-_overexpressing MTB strains (red) without drug (pale, dashed lines) and post treatment with 3μM ETH (Panel A) and 2μM INH (Panel C). (B, D) Time-courses of metabolic activity measured by Alamar Blue reduction. Data represent mean ± standard deviation of three biological replicates.