Scalable multi-sample single-cell data analysis by Partition-Assisted Clustering and Multiple Alignments of Networks (original) (raw)
Fig 5
Schematic analogy of MAN.
Consider a deck of networks (in analogy to cards), with each “suit” representing a sample and each “rank” representing a unique network structure. The networks are aligned by similarity and organized on a dendrogram. The tree is cut (red line) at the optimal level (by elbow point analysis, see S8 Fig) to output k clades. Within each clade, the network structures are similar or the same. If the same sample has multiple networks in the same clade, then these networks are merged (black box around same cards).