The Zebrafish Mutants dre, uki, and lep Encode Negative Regulators of the Hedgehog Signaling Pathway (original) (raw)
Figure 5
MO Injection Experiments against Su(fu), Hip, and Ptc2
(A) Dorsal view of the eye showing the lens in the eye chamber.
(B–D) Dorsal view of embryos injected with the indicated MOs, resulting in a phenocopy of dre, uki, and lep mutants.
(E) A wild-type ear showing the presence of the dorsolateral septum (arrow), which is not present after injections with the indicated MOs (F–H, arrow).
(I) Injections with control MOs against the initiation codon of Su(fu) results in chevron-shaped somites with an angle of 97°.
(J) Injection of MOs against Su(fu) results in a more obtuse angle of the somite (126°).