Allele-Specific Chromatin Immunoprecipitation Studies Show Genetic Influence on Chromatin State in Human Genome (original) (raw)
Figure 3
Clustering of the Samples by Family with Allelic Chromatin-Binding Activity
We analyzed three pair-wise combinations of CEPH families, 1347 (red), 1331 (blue), and 1413 (green) using PCA. All data were generated using the version 2 of the 10K SNP chip. PCAs were performed with the total intensity (A + B) (figures on the left side) as well as with the relative binding intensity (A/A + B) (figures on the right side). Similar PCA projections with more complete sample labeling are shown in Figure S3, Figure S4, and Figure S5. The samples are described in Table S1.
Ac, histone H3 lysine 9/14 acetylation; K4, histone H3 lysine 4 dimethylation; input, DNA from whole cell extract; gDNA, genomic DNA.